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Primidone

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Primidone is an anticonvulsant that is metabolized to phenylethylmalonamide (PEMA) and phenobarbital[1], historically considered a prodrug of phenobarbital[2], nevertheless it is superior against tremor [3] [4] Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner

ATC

antiepileptic drugs


primidone
[5]

[6]

Links

Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs

Factors Associated with Ordering Laboratory Monitoring of High-Risk Medications

Q420383 at Wikidata  Interwiki via Wikidata


References

References:
  1. ↑ Practice Parameter:Therapies for essential tremor Report of the Quality Standards Subcommittee of the American Academy of Neurology
  2. ↑ The history of barbiturates a century after their clinical introduction
  3. ↑ Essential Tremor: What We Can Learn from Current Pharmacotherapy
  4. ↑ Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors
  5. ↑ http://www.whocc.no/atc_ddd_index/?code=N03AA03
  6. ↑ Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner
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