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Primidone: Difference between revisions

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Primidone is an [[AED|anticonvulsant]] that is metabolized to phenylethylmalonamide (PEMA) and phenobarbital<ref>[http://www.neurology.org/content/64/12/2008.full.pdf+html Practice Parameter:Therapies for essential tremor Report of the Quality Standards Subcommittee of the American Academy of Neurology]</ref>, historical considered a prodrug of phenobarbital<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424120/pdf/ndt-0104-329.pdf The history of barbiturates a century after their clinical introduction]</ref>, nevertheless it is superior against tremor
Primidone is an [[AED|anticonvulsant]] that is metabolized to phenylethylmalonamide (PEMA) and [[phenobarbitone|phenobarbital]]<ref>[http://www.neurology.org/content/64/12/2008.full.pdf+html Practice Parameter:Therapies for essential tremor Report of the Quality Standards Subcommittee of the American Academy of Neurology]</ref>, historical considered a prodrug of phenobarbital<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424120/pdf/ndt-0104-329.pdf The history of barbiturates a century after their clinical introduction]</ref>, nevertheless it is superior against tremor
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790207/pdf/tre-06-356-7522-1.pdf Essential Tremor: What We Can Learn from Current Pharmacotherapy]</ref>
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790207/pdf/tre-06-356-7522-1.pdf Essential Tremor: What We Can Learn from Current Pharmacotherapy]</ref>
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766376/pdf/nihms-480525.pdf Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors]</ref>
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766376/pdf/nihms-480525.pdf Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors]</ref>

Revision as of 18:33, 25 November 2016