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Primidone: Difference between revisions
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historical considered a prodrug of phenobarbital, nevertheless it is superior against tremor | Primidone is an anticonvulsant that is metabolized to phenylethylmalonamide (PEMA) and phenobarbital<ref>http://www.neurology.org/content/64/12/2008.full.pdf+html Practice Parameter:Therapies for essential tremor Report of the Quality Standards Subcommittee of the American Academy of Neurology</ref>, historical considered a prodrug of phenobarbital, nevertheless it is superior against tremor | ||
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790207/pdf/tre-06-356-7522-1.pdf Essential Tremor: What We Can Learn from Current Pharmacotherapy]</ref> | <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790207/pdf/tre-06-356-7522-1.pdf Essential Tremor: What We Can Learn from Current Pharmacotherapy]</ref> | ||
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766376/pdf/nihms-480525.pdf Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors]</ref> | <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766376/pdf/nihms-480525.pdf Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors]</ref> | ||
Revision as of 17:30, 25 November 2016
Primidone is an anticonvulsant that is metabolized to phenylethylmalonamide (PEMA) and phenobarbital[1], historical considered a prodrug of phenobarbital, nevertheless it is superior against tremor [2] [3] Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner
ATC
http://www.whocc.no/atc_ddd_index/?code=N03AA03 [4]
Links
Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs
Factors Associated with Ordering Laboratory Monitoring of High-Risk Medications
Notes
- ↑ http://www.neurology.org/content/64/12/2008.full.pdf+html Practice Parameter:Therapies for essential tremor Report of the Quality Standards Subcommittee of the American Academy of Neurology
- ↑ Essential Tremor: What We Can Learn from Current Pharmacotherapy
- ↑ Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors
- ↑ Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner