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Nephrotic syndrome: Difference between revisions

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Nephrotic syndrome is a nonspecific kidney disorder characterized by a number of signs of disease: proteinuria, hypoalbuminemia and edema. It is characterized by an increase in permeability of the capillary walls of the glomerulus leading to the presence of high levels of protein passing from the blood into the urine (proteinuria at least 3.5 grams per day per 1.73m<sup>2</sup> body surface area); (> 40 mg per square meter body surface area per hour) low levels of protein in the blood (hypoproteinemia or hypoalbuminemia), ascites and in some cases, edema; high cholesterol (hyperlipidaemia or hyperlipemia) and a predisposition for coagulation<ref>[https://en.wikipedia.org/w/index.php?title=Nephrotic_syndrome&oldid=669864176 WIKIPEDIA:]</ref>
Nephrotic syndrome is a nonspecific kidney disorder characterized by a number of signs of disease: proteinuria, hypoalbuminemia and edema. It is characterized by an increase in permeability of the capillary walls of the glomerulus leading to the presence of high levels of protein passing from the blood into the urine (proteinuria at least 3.5 grams per day per 1.73m<sup>2</sup> body surface area); (> 40 mg per square meter body surface area per hour) low levels of protein in the blood (hypoproteinemia or hypoalbuminemia), ascites and in some cases, edema; high cholesterol (hyperlipidaemia or hyperlipemia) and a predisposition for coagulation<ref>[https://en.wikipedia.org/w/index.php?title=Nephrotic_syndrome&oldid=669864176 WIKIPEDIA:]</ref>
==Links==
==Links==


*[http://www.nature.com/ki/journal/v43/n6/pdf/ki1993194a.pdf A randomized trial of cyclosporine in steroid-resitant idiopathic nephrotic syndrome]
*[http://www.nature.com/ki/journal/v43/n6/pdf/ki1993194a.pdf A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome]
*[http://www.nature.com/ki/journal/v44/n3/pdf/ki1993292a.pdf The increased risk of coronary heart disease asociated with nephrotic syndrome]
*[http://www.nature.com/ki/journal/v44/n3/pdf/ki1993292a.pdf The increased risk of coronary heart disease asociated with nephrotic syndrome]
*[http://www.jgld.ro/2015/2/22.html Nephrotic syndrome after infliximab treatment in a patient with ulcerative colitis] [http://www.jgld.ro/2015/2/22.pdf PDF]
*[http://www.jgld.ro/2015/2/22.html Nephrotic syndrome after infliximab treatment in a patient with ulcerative colitis] [http://www.jgld.ro/2015/2/22.pdf PDF]
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===Therapy===
===Therapy===
Jacob Churga, Renee Habibb, Richard H.R. Whitec 1970
*Jacob Churg, Renee Habib, Richard H.R. White 1970
[http://www.sciencedirect.com/science/article/pii/S0140673670919057 Pathology of the Nephrotic Syndrome im Children: A Report for the International Study of Kidney Disease in Children Lancet] 295:1299–1302
[http://www.sciencedirect.com/science/article/pii/S0140673670919057 Pathology of the Nephrotic Syndrome im Children: A Report for the International Study of Kidney Disease in Children Lancet] 295:1299–1302
*[http://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=4;spage=743;epage=746;aulast=Barman Barman H, Sirie R, Duwarah SG. Effective ultrafiltration with acute peritoneal dialysis in a child with diuretic-resistant nephrotic edema. Saudi J Kidney Dis Transpl [serial online] 2015 [cited 2015 Jul 23];26:743-6]
*[http://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=4;spage=743;epage=746;aulast=Barman Barman H, Sirie R, Duwarah SG. Effective ultrafiltration with acute peritoneal dialysis in a child with diuretic-resistant nephrotic edema. Saudi J Kidney Dis Transpl [serial online] 2015 [cited 2015 Jul 23];26:743-6]

Revision as of 00:17, 24 July 2015

Disease classification WHO
N04 Nephrotic syndrome

Nephrotic syndrome is a nonspecific kidney disorder characterized by a number of signs of disease: proteinuria, hypoalbuminemia and edema. It is characterized by an increase in permeability of the capillary walls of the glomerulus leading to the presence of high levels of protein passing from the blood into the urine (proteinuria at least 3.5 grams per day per 1.73m2 body surface area); (> 40 mg per square meter body surface area per hour) low levels of protein in the blood (hypoproteinemia or hypoalbuminemia), ascites and in some cases, edema; high cholesterol (hyperlipidaemia or hyperlipemia) and a predisposition for coagulation[1]

Links

Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome Molecular Cell 1, 575–582

Therapy

  • Jacob Churg, Renee Habib, Richard H.R. White 1970

Pathology of the Nephrotic Syndrome im Children: A Report for the International Study of Kidney Disease in Children Lancet 295:1299–1302

Notes