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Febrile seizure

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A febrile seizure, also known a febrile convulsion, is a seizure associated with a high body temperature but without any serious underlying health issue,

According to the current state of knowledge, the GABA-A receptor has a temperature-sensitive subunit, whereby a temperature increase leads to a disruption of the GABAergic inhibitory transmission. GABA has a central role in the brain in inhibiting and attenuating neuronal excitement. Thus, it is easy to understand that hyperthermia-induced blockade of these transmitter-receptor systems leads to general over-excitability and seizure tendency. On the other hand, it is known that endogenous pyrogens themselves can lower the seizure threshold of the brain. These are, for example, tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6, which lead to fever via the stimulation of cyclooxygenase-2 with subsequent increase in prostaglandin E2. A reduction in fever inhibits only the cyclooxygenase-2, but not the release of these pyrogens. However, an elevated temperature itself can inhibit the release of these pyrogens. This may also be justified, why reducing the fever does not prevent febrile seizures[1]


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  1. [Einfluss von Hyperthermie auf die intrazelluläre Expression proinflammatorischer Zytokine in menschlichen Monozyten]