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Choi, YM, and Kim, KH (2015). Etifoxine for Pain Patients with Anxiety

etifoxine is an anticonvulsant and ansiolytic agent. It is not recommended under the age of 18 years.[1]

The known mechanism of action is potentiation of GABAA receptor, via stimulation of neurosteroid production. The etifoxine therapy promoted the regeneration of axons [2] [3]


Etifoxine promotes glial‑derived neurotrophic factor‑induced neurite outgrowth in PC12 cells

do Rego JL, Vaudry D, Vaudry H (2015) The Non-Benzodiazepine Anxiolytic Drug Etifoxine Causes a Rapid, Receptor-Independent Stimulation of Neurosteroid Biosynthesis. PLoS ONE 10(3): e0120473. doi:10.1371/journal.pone.0120473