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Eslicarbazepine: Difference between revisions

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[[File:1Eslicarbazepine acetate structure.svg.png|thumb]]
[[File:1Eslicarbazepine acetate structure.svg.png|thumb]]


S-licarbazepine is an [[antiepileptic drug|AED]]. Adjunctive eslicarbazepine led to seizure reduction in patients with severe myoclonic epilepsy of infancy<ref>Severe myoclonic epilepsy of infancy: Seizure reduction during adjunctive eslicarbazepine in two cases</ref><ref>[http://onlinelibrary.wiley.com/doi/10.1111/epi.12894/epdf Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial]</ref>
S-licarbazepine is an [[antiepileptic drug|AED]]. Adjunctive eslicarbazepine led to seizure reduction in patients with severe myoclonic [[epilepsy]] of infancy<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501557/pdf/main.pdf Severe myoclonic epilepsy of infancy: Seizure reduction during adjunctive eslicarbazepine in two cases]</ref><ref>[http://onlinelibrary.wiley.com/doi/10.1111/epi.12894/epdf Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial]</ref>


==Pharmacy and chemistry==
==Pharmacy and chemistry==


Eslicarbamazepine acetate is an once-daily antiepileptic that was approved in 2009 by the [[European Medicines Agency|EMA]] (Zerebix <sup>TM</sup>) and recently by the American [[FDA]]<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480532/pdf/10.1177_1756285615589711.pdf A review of the efficacy and safety of eslicarbazepine acetate in the management of partial-onset seizures]</ref>
Eslicarbamazepine acetate is an once-daily antiepileptic that was approved in 2009 by the [[European Medicines Agency|EMA]] (Zerebix <sup>TM</sup>) and recently by the American [[FDA]]<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480532/pdf/10.1177_1756285615589711.pdf A review of the efficacy and safety of eslicarbazepine acetate in the management of partial-onset seizures]</ref>
Eslicarbamazepine is the prodrug of S-licarbazepine, both oxcarbazapine and eslicarbazepine metabolize same, different to carbazepine; the latter metabolizes to CBZ 10,11-epoxide (Hainzl et al, 2001)<ref>https://www.dovepress.com/clinical-utility-of-eslicarbazepine-current-evidence-peer-reviewed-article-DDDT</ref>
Eslicarbamazepine is the prodrug of S-licarbazepine, both oxcarbazapine and eslicarbazepine metabolize same, different to [[carbazepine]]; the latter metabolizes to CBZ 10,11-epoxide (Hainzl et al, 2001)<ref>https://www.dovepress.com/clinical-utility-of-eslicarbazepine-current-evidence-peer-reviewed-article-DDDT</ref>


==Pharmacology==
==Pharmacology==


[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448990/ Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action]
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448990/ Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action]
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330027/ Clinical utility of eslicarbazepine: current evidence]
===Mild inducers===
After de Leon the following AED groups as mild inducers:
*clobazam
*eslicarbazepine
*[[rufinamide]]
*felbamate
*[[lamotrigine]]
*[[oxcarbazepine]]
*[[topiramate]]
*vigabatrin
*[[valproic acid|VPA]]
 
<ref>[http://apps.elsevier.es/watermark/ctl_servlet?_f=10&pident_articulo=90431353&pident_usuario=0&pcontactid=&pident_revista=486&ty=55&accion=L&origen=zonadelectura&web=www.elsevier.es&lan=en&fichero=486v08n02a90431353pdf001.pdf The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part I: A summary of the current state for clinicians ]</ref>
 
===Cutaneous adverse effects===
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231563/ Cutaneous adverse drug reaction type erythema multiforme major induced by eslicarbazepine]
 
==ATC code N03==
==ATC code N03==
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5
|colspan=2| <center>
|colspan=2| <center>
: [[wikipedia:eslicarbazepine|eslicarbazapine]]
: [[wikipedia:eslicarbazepine|eslicarbazepine]]
<ref>http://www.whocc.no/atc_ddd_index/?code=N03AF04</ref></center>
<ref>http://www.whocc.no/atc_ddd_index/?code=N03AF04</ref></center>
|}
|}
{{Wikidata|Q410273}}
==Bioequivalence==
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689905/pdf/40268_2013_Article_16.pdf Bioequivalence of eslicarbazepine acetate from two different sources of its active product ingredient in healthy subjects]


==References==
==References==

Latest revision as of 19:17, 13 October 2017

S-licarbazepine is an AED. Adjunctive eslicarbazepine led to seizure reduction in patients with severe myoclonic epilepsy of infancy[1][2]

Pharmacy and chemistry

Eslicarbamazepine acetate is an once-daily antiepileptic that was approved in 2009 by the EMA (Zerebix TM) and recently by the American FDA[3] Eslicarbamazepine is the prodrug of S-licarbazepine, both oxcarbazapine and eslicarbazepine metabolize same, different to carbazepine; the latter metabolizes to CBZ 10,11-epoxide (Hainzl et al, 2001)[4]

Pharmacology

Mild inducers

After de Leon the following AED groups as mild inducers:

[5]

Cutaneous adverse effects

Cutaneous adverse drug reaction type erythema multiforme major induced by eslicarbazepine

ATC code N03

eslicarbazepine
[6]

Q410273 at Wikidata  Interwiki via Wikidata


Bioequivalence

Bioequivalence of eslicarbazepine acetate from two different sources of its active product ingredient in healthy subjects

References