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Carbamazepine: Difference between revisions
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[[File:5H-Dibenzo(b,f)azepine numbering.svg.png|thumb|left]] | |||
structure related to [[imipramin]][[File:Carbamazepine3Dan.gif|miniature]] | |||
[[File:Tegretol.jpg|thumb|left]] | |||
can form five polymorphic states, with low water solubility | |||
<ref>Halliwell RA, Bhardwaj RM, Brown C, Briggs NEB, Dunn J, Robertson J,Nordon A, Florence AJ, Spray drying as a reliable route to produce metastable carbamazepine form IV, Journal of Pharmaceutical Sciences (2017), doi: 10.1016/j.xphs.2017.03.045.</ref> | |||
== == | |||
Carbamazepine teratogenicity is relatively specific to [[spina bifida]], though the risk is less than with [[valproate|valproic acid]]<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996546/ Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study]</ref> | |||
<ref>[http://www.scielosp.org/pdf/spm/v54n6/a06v54n6.pdf Malformaciones congenitas en hijos de madres epilépticas con y sin tratamiento con anticonvulsivantes]</ref> | |||
[[Stevens-Johnson syndrome]]<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372085/ HLA-B*15:21 and carbamazepine-induced Stevens-Johnson syndrome: pooled-data and in silico analysis.]</ref><ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296452/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296452/ Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case]</ref> | |||
<ref>https://www.drugs.com/monograph/carbamazepine.html</ref> | |||
"there is any association between sexual dysfunctions and various [[antiepileptic drug|AEDs]] in the treatment, except for carbamazepine" | |||
<ref>[https://www.ncbi.nlm.nih.gov/pubmed/28315500 Relation between sexual dysfunctions and epilepsy, type of epilepsy, type of antiepileptic drugs: a prospective study]</ref> | |||
==Links== | ==Links== | ||
[https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(17)30246-0 Spray drying as a reliable route to produce metastable carbamazepine form IV] | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376916/ Antiepileptic Drugs Impair Shortening of Isolated Cardiomyocytes] | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376916/ Antiepileptic Drugs Impair Shortening of Isolated Cardiomyocytes] | ||
[https://www.jstage.jst.go.jp/article/internalmedicine/56/8/56_56.7910/_pdf Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine] | |||
[https://www.ncbi.nlm.nih.gov/pubmed/28401072 The Investigation of Insulin Resistance in Two Groups of Epileptic Patients Treated with Sodium Valproate and Carbamazepine] | |||
===Rapamycin=== | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321171/ Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease] | |||
===Extended release=== | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279715/pdf/nihms614995.pdf The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder] | |||
==[[ATC]]== | |||
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5 | |||
|colspan=2| <center> | |||
: [[wikipedia:carbamazepine|carbamazepine]] | |||
[http://www.whocc.no/atc_ddd_index/?code=N03AF01 N03AF01]</center> | |||
|} | |||
<ref>https://www.whocc.no/atc_ddd_index/?code=N03AF01</ref> | |||
{{refs}} | |||
[[Category:anticonvulsants]] | |||
Latest revision as of 15:10, 21 May 2019
azepine_numbering.svg.png)
structure related to imipramin
can form five polymorphic states, with low water solubility [1]
Carbamazepine teratogenicity is relatively specific to spina bifida, though the risk is less than with valproic acid[2] [3]
Stevens-Johnson syndrome[4][5] [6]
"there is any association between sexual dysfunctions and various AEDs in the treatment, except for carbamazepine" [7]
Links
Spray drying as a reliable route to produce metastable carbamazepine form IV
Antiepileptic Drugs Impair Shortening of Isolated Cardiomyocytes
Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine
Rapamycin
Extended release
The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder
ATC
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